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Clomid products
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Effective dosage:
25-100 mcg/day
Additional comments:
Drug Class: Synthetic thyroid hormone.
Comments: Significant suppression of Thyroid function
during use.
Arimidex detailed information:
Clomid is the anti-estrogen of choice for
improving recovery of natural testosterone production after
a cycle, improving testosterone production of endurance
athletes, and is also effective in reducing risk of
gynecomastia during a cycle employing aromatizable steroids.
While it has been claimed that Clomid "stimulates"
production of LH and therefore of testosterone, in fact
Clomid's activity is achieved not by stimulation of the
hypothalamus and pituitary, but by blocking their inhibition
by estrogen.
Clomid is a mixed estrogen agonist/antagonist
(activator/blocker) which, when bound to the estrogen
receptor, puts it in a somewhat different conformation
(shape) than does estradiol. The estrogen receptor requires
binding of an estrogen or drug at its binding site and also
the binding of any of several cofactors at different sites.
Without the binding of the cofactor, the estrogen receptor
is inactive. Different tissues use different cofactors. Some
of these cofactors are able to bind to the estrogen
receptor/Clomid complex, but others are blocked due to the
change in shape. The result is that in some tissues Clomid
acts as an antagonist - the cofactor used in that tissue
cannot bind and so the receptor remains inactive - and in
others Clomid acts as an agonist (activator), because the
cofactors used in that tissue are able to bind.
Clomid is an effective antagonist in the hypothalamus and
in breast tissue. It is an effective agonist in bone tissue,
and for improving blood cholesterol.
Clomid also has the property of reducing the adverse effect
of exercise-induced damage of muscle tissue. This is very
significant for endurance athletes but is not very
significant, if at all significant, with reasonable weight
training. Clomid does not perceptibly affect gains of the
weight trainer either favorably or adversely in my
experience.
The drug seems to have estrogenic effects on mood, which
can be beneficial (improving relationships with women by
improving empathy) or can yield depression or PMS-like
symptoms, but for most users there is no significant effect
either way.
The claim that duration of intake should not exceed 10-14
days is incorrect. Clinical studies with male patients have
been for periods of a year or longer. This error probably
originates from the fact that, for use in women, due to the
menstrual cycle there would obviously be no point in trying
to stimulate ovulation all four weeks of the month. Thus,
use in women is limited to 10-14 days. That limitation is
not because of toxicity.
Clomid is in fact useful throughout a cycle if
aromatizable drugs are being used. We do think however that
to be conservative, one should use it no more than 2/3 of
the time throughout the year or a little less.
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